CTRP3 as a novel biomarker in the plasma of Saudi children with autism

Author:

Alhakbany Manan1,Al-Ayadhi Laila12,El-Ansary Afaf234

Affiliation:

1. Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia

2. Autism Research and Treatment Center, Riyadh, Saudi Arabia

3. CONEM Saudi Autism Research Group, King Saud University, Riyadh, Saudi Arabia

4. Central Laboratory, Female Center for Scientific and Medical Studies, King Saud University, Riyadh, Saudi Arabia

Abstract

Background C1q/tumor necrosis factor-related protein-3 (CTRP3) has diverse functions: anti-inflammation, metabolic regulation, and protection against endothelial dysfunction. Methods The plasma level of CTRP3 in autistic patients (n = 32) was compared to that in controls (n = 37) using ELISA. Results CTRP3 was higher (24.7% with P < 0.05) in autistic patients than in controls. No association was observed between CTRP3 and the severity of the disorder using the Childhood Autism Rating Scale (CARS). A positive correlation between CARs and the age of patients was reported. Receiver operating characteristic (ROC) analysis demonstrated a low area under the curve (AUC) for all patients (0.636). Low AUCs were also found in the case of severe patients (0.659) compared to controls, but both values were statistically significant (P ≤ 0.05). Despite the small sample size, we are the first to find an association between CTRP3 and autism spectrum disorder (ASD).

Funder

National Plan for Science Technology and Innovation

King Abdulaziz City for Science and Technology, Saudi Arabia

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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