Ficus septicaplant extracts for treating Dengue virusin vitro-Reference-Cited by-同舟云学术

Ficus septicaplant extracts for treating Dengue virusin vitro

Published:2017-06-08 Issue: Volume:5 Page:e3448
ISSN:2167-8359
Container-title:PeerJ
language:en
Short-container-title:

Author:

Huang Nan-Chieh¹,Hung Wan-Ting²,Tsai Wei-Lun³,Lai Feng-Yi⁴,Lin You-Sheng⁵,Huang Mei-Shu⁵,Chen Jih-Jung⁶,Lin Wei-Yu⁷,Weng Jing-Ru⁸,Chang Tsung-Hsien⁵⁹

Affiliation:

1. Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan

2. Section of critical care medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan

3. Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

4. Deparment of Nursing, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan

5. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

6. Faculty of Pharmacy, National Yang-Ming University, Taipei, Taiwan

7. Department of Pharmacy, Kinmen Hospital, Kinmen, Taiwan

8. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan

9. Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan

Abstract

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to theFlaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plantsin vitro; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem fromFicus septicaBurm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelopepicornavirus, Aichi virus, was not inhibited by treatment withF. septicaextracts.F. septicamay be a candidate antiviral drug against an enveloped virus such as DENV.

Funder

Kaohsiung Armed Forces General Hospital Zuoying Branch

Ministry of Health and Welfare

Kaohsiung Veterans General Hospital, Taiwan

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://peerj.com/articles/3448.pdf

Reference22 articles.

1. Dengue;Abel;New England Journal of Medicine,2012