The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype-Reference-Cited by-同舟云学术

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype

Published:2013-10-01 Issue: Volume:1 Page:e174
ISSN:2167-8359
Container-title:PeerJ
language:en
Short-container-title:

Author:

Zhao Lei¹²,Wink Michael²

Affiliation:

1. Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA, USA

2. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://peerj.com/articles/174.pdf

Reference61 articles.

1. Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens;Albino;Cell Cycle,2004

2. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities;Astulla;Journal of Natural Medicines,2008

3. p53 represses Sp1 DNA binding and HIV-LTR directed transcription;Bargonetti;Cell Molecular Biology,1997

4. Telomerase activity and telomere detection during early bovine development;Betts;Developmental Genetics,1999

5. Extension of life-span by introduction of telomerase into normal human cells;Bodnar;Science,1998

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