The relationship between leptin and periodontitis: a literature review

Author:

Guo Zhijiao1,Peng Yanhui1,Hu Qiaoyu1,Liu Na2,Liu Qing1

Affiliation:

1. Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China

2. Department of Preventive Dentistry, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei Province, China

Abstract

Leptin is a peptide hormone that regulates energy balance, immune inflammatory response, and bone metabolism. Several studies have demonstrated a relationship between leptin and periodontitis, a local inflammatory disease that progressively weakens the supporting structures of the teeth, eventually leading to tooth loss. This article reviews the existing literature and discusses leptin’s basic characteristics, its relationship with periodontitis, and its effects on periodontal tissue metabolism.

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference62 articles.

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2. Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic periodontitis and chronic periodontitis patients with type 2 diabetes mellitus;Ahuja;Journal of Investigative and Clinical Dentistry,2019

3. Pathophysiological aspects in the interaction between periodontal disease and diabetes;Anton;Romanian Journal of Medical and Dental Education,2020

4. Metabolic syndrome and periodontitis: is oxidative stress a common link?;Bullon;Journal of Dental Research,2009

5. Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice;Chaves;Journal of Applied Oral Science,2022

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