AMELIORATIVE EFFECTS OF BAICALIN AGAINST EXPOSURE TO FLUMETHRIN IN MALE RATS

Abstract

Flumethrin is a pyrethroid insecticide, while baicalin is a flavonoid with antioxidant, anti-inflammatory, and anticarcinogenic properties. The aim of this study was to investigate the effects of baicalin on biochemical parameters and lipid peroxidation flumethrin-induced in rats. In the study, 42 rats were divided into six groups with each group comprising seven rats. Flumethrin was administrated 15 mg/kg b.w. to second group, flumethrin+baicalin 50 mg/kg b.w. was administrated to third group, flumethrin+baicalin 100 mg/kg b.w. was administrated to fourth group, baicalin 50 mg/kg b.w. was administrated to fifth group, and baicalin 100 mg/kg b.w. was administrated to sixth group. After, blood and tissue samples were collected for biochemical and histopathological evaluations. According to obtained results, when flumethrin-induced group was compared to control, alkaline phosphatase, cholesterol, blood urea nitrogen, uric acid and total protein levels significantly decreased. Also, kidney catalase and plasma glutatione peroxidase, liver catalase and superoxide dismutase activities decreased, but both kidney and liver nitric oxide and melondialdehyde levels increased in flumethrin-induced group. Flumethrin caused to histopathological alterations in tissues. On the other hand, statistically, kidney catalase and plasma glutatione peroxidase, liver catalase and superoxide dismutase activities increased, but nitric oxide and melondialdehyde levels decreased in all groups given baicalin. In additionally, baicalin affected to some biochemical parameters (p<0.05) and regressed to tissue damage. The obtained biochemical results were consistent with histopathological results. In conclusion, this study suggests that baicalin can ameliorate oxidative stress and tissue damage in flumethrin-induced subacute toxication in rats.