Research progress on the mechanisms, assessment methods, and intervention strategies for glioma-related cognitive impairment

Abstract

Glioma-related cognitive dysfunction has emerged as a significant issue that affects the quality of life of patients. This paper aims to review the latest advancements in research on the mechanisms, assessment methods, and intervention strategies for glioma-induced cognitive impairment. First, it explored the potential mechanisms underlying glioma-related cognitive dysfunction, including the influence of tumor location, surgical interventions, and radiotherapy/chemotherapy. The focus is on recent discoveries in areas such as neuroinflammation, compromised neuroplasticity, and alterations in white matter integrity. Secondly, the paper examines widely used cognitive assessment tools, such as neuropsychological tests and imaging techniques, and assesses their suitability and limitations in glioma patients. Finally, the paper discusses the potential applications of pharmacological treatments, neurorehabilitation exercises, and emerging technologies (such as transcranial magnetic stimulation and brain-computer interfaces) in mitigating cognitive dysfunction. Drawing from the current literature, this review offers recommendations for future research directions, aiming to provide valuable insights into clinical treatment and research efforts.