Risk Assessment of Silicosis and Lung Cancer Mortality associated with Occupational Exposure to Crystalline Silica in Iran

Abstract

Background: Exposure to crystalline silica has long been identified to be associated with lung diseases. Therefore, the present study aimed to assess the risk of silicosis and lung cancer associated with occupational exposure to crystalline silica in Iran. Study Design: It is a systematic review study. Methods: Different databases were searched, and the Cochrane method was used for the systematic review. Thereafter, cumulative exposure to crystalline silica (mg/m3 -y) was calculated in every industry. The relative risk of death from silicosis was performed using Mannetje’s method. Based on the geometric mean of exposure, the lung cancer risk of exposure to crystalline silica was also calculated. Results: As evidenced by the results, worker’s exposure to silica ranged from a geometric mean of 0.0212- 0.2689 mg/m3 (Recommended standard by the American Conference of Governmental Industrial Hygienists (ACGIH) was 0.025 mg/m3 ), which is generally higher than the occupational exposure limit recommended by National Institute for Occupational Safety and Health (NIOSH), ACGIH, and occupational exposure limits. The relative risk of silicosis was in the range of 1 to 14 per 1000 people, and the risk of lung cancer in workers ranged from 13-137 per 1000 people. Conclusion: Since workers are at considerable risk of cancer due to exposure to silica in Iran, exposure control programs need to be implemented in workplaces to decrease the concentration of silica.