Sodium Bicarbonate versus Statins to Prevent Contrast-induced Acute Kidney Injury: A Comprehensive Review
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Published:2021-03-31
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ISSN:1735-403X
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Container-title:Pharmaceutical Sciences
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language:en
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Short-container-title:Pharm Sci
Author:
Dolati SanamORCID,
Mahmoodpoor Ata,
Gharizadeh Nafiseh,
Gholipouri Saina,
Soleimanpour HassanORCID
Abstract
Iodinated contrast agents are commonly used in diagnostic radiography techniques along with therapeutic interventions. Contrast-Induced Acute Kidney Injury (CI-AKI) is a significant problem of all angiographic procedures, triggered by the use of Iodinated Contrast Media (ICM). There are conflicting data concerning the prevention and treatment of CI-AKI. Numerous approaches have been studied to prevent CI-AKI, but the therapy of choice remains undetermined. The cornerstones of CI-AKI prevention include low-osmolar ICM and intravenous hydration. The recommended hydration must be achieved by means of an isotonic solution of saline. Statins were tested against AKI due to their anti-inflammatory action and antioxidant effect on endothelial function. Novel approaches are required to investigate the short-term effects of high dosage atorvastatin versus sodium bicarbonate on CI-AKI prevention. The objective of this review is to compare the findings of various studies that had applied different doses of statins, sodium bicarbonate, and other agents for preventing CI-AKI.
Publisher
Maad Rayan Publishing Company
Subject
General Pharmacology, Toxicology and Pharmaceutics,Pharmaceutical Science