Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats

Author:

Parsania Sara1,Salehpoor Somaye2,Sadrr Ameli Maryam3,Abdi Morteza4,Shokoohi Majid2ORCID,Rahimi Mamaghani Alireza2,Majdi Leila5

Affiliation:

1. Department of Research and Development, Aras Part Medical Pharmacetical International Company, Tabriz, Iran.

2. Clinical Research Development Unit of Tabriz Vali Asr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

3. Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

4. Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

5. Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Objectives: This study aims to comprehensively assess the therapeutic potential of clove extract in mitigating testicular damage and preserving male reproductive function under hypoxic conditions in male rats. Materials and Methods: We randomly divided 24 male rats into three groups: a hypoxia group that just received normal saline, a hypoxia + clove extract (4 mg/kg) group, and a sham operation group without treatment. After eight weeks, the serum level of oxidative stress parameters was examined, and the testicle histopathological examination, such as seminiferous tubule diameters and epithelium thickness, was assessed. Results: The serum malondialdehyde (MDA) concentration was significantly enhanced in the hypoxic group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) declined (P<0.05). The diameters and thickness of the seminiferous tubule were diminished notably (P<0.05). Johnson’s score decreased in the hypoxic group. Treatment with clove extract also led to improvements in this parameter. Conclusions: Our study provides compelling evidence for the therapeutic potential of clove extract in mitigating testicular injury associated with varicocele-induced testicular hypoxia in male rats.

Publisher

Maad Rayan Publishing Company

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3