Is netrin-1 a reliable inflammatory marker for periodontitis?

Author:

Abdulfattah Sarah Yasser1ORCID,Baiomy Azza Abdel Baky2ORCID,Youssef Jilan Mohammed1ORCID

Affiliation:

1. Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt

2. Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Abstract

Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05). Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.

Publisher

Maad Rayan Publishing Company

Subject

Plant Science,Forestry

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