Evaluation of the Prevalence of Anti-transglutaminase 2 and 6 Antibodies in Patients with Sero-Positive Multiple Sclerosis-Reference-Cited by-同舟云学术

Evaluation of the Prevalence of Anti-transglutaminase 2 and 6 Antibodies in Patients with Sero-Positive Multiple Sclerosis

Published:2024-01-31 Issue:1 Volume:16 Page:47-51
ISSN:2008-5249
Container-title:Middle East Journal of Digestive Diseases
language:en
Short-container-title:Middle East J Dig Dis

Author:

Emami Mohammad Hassan¹²^ORCID,Najafi Mohammad Reza³⁴,Allahdadian Sepideh⁵,Mohammadzadeh Samane¹²,Jamali Nahid⁶⁷,Lalazarian Anasik¹²,Shaygan Nejad Vahid³⁴,Maghool Fatemeh¹²^ORCID

Affiliation:

1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2. Pooya Zist-Mabna Hakim Company, Poursina Hakim Institute, Isfahan, Iran

3. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran

4. Isfahan Neurosciences Research Centre (INRC), Isfahan University of Medical Sciences, Isfahan, Iran

5. Department of Neurology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

6. Department of Health Policy, School of Management and Information, Iran University of Medical Sciences, Tehran

7. Iranian Celiac Association, Isfahan, Iran

Abstract

Background: Gluten sensitivity (GS) is one of the gluten-related disorders (GRDs). Patients with GS may have serum antibodies against tissue transglutaminase (tTG) (IgA and IgG) without any evidence of enteropathy. We aimed to evaluate both tTG-6 and tTG-2 antibodies to determine the prevalence of seropositive tTG-2 and tTG-6 antibodies in patients with multiple sclerosis (MS). Methods: In this cross-sectional study, we carried out serological tests (IgA & IgG anti-tTG-6 and tTG-2 antibodies) in patients with MS. Results: Seventy-two patients with MS were included in this study. Of them, seropositive patients for total (IgA+IgG) of tTG-6 and tTG-2 autoantibodies were 9.7% (95% CI, 4.2-18) and 5.6% (95% CI, 1.4-12.5), respectively. Conclusion: Anti-tTG-6 antibody testing may be necessary for early diagnosis of GS in patients with MS. More studies with larger sample sizes are warranted to confirm these data.

Publisher

Maad Rayan Publishing Company

Reference44 articles.

1. Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

2. Dermatitis herpetiformis;Plotnikova N;Skin Therapy Lett,2013

3. Rare Neurological Manifestation of Celiac Disease

4. Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity