Association of AT1R (A1166C) gene polymorphisms and hypertension: A study in south Indian population and meta-analysis

Abstract

Introduction: Hypertension is a multi-factorial disease caused by several etiologies. It has been reported that hypertension has been linked to AT1R A1166C polymorphism, but the previous studies in Indian populations remain controversial. Objectives: In this study, we aimed to investigate the AT1R A1166C gene polymorphism with the risk of hypertension in the south Indian populations. Patients and Methods: The 179 subjects were considered in the association study utilizing polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) genotyping technique, yielding no significant association in the dominant and allelic models P=0.76 and P=0.76 respectively. Additionally, to determine the relationship between the AT1R gene A1166C polymorphism and hypertension in the Indian population, a metaanalysis was conducted. The retrieved seven case-control studies on Indian populations are conducted to determine how strongly genes are associated using the pooled odds ratio (OR) and 95% confidence intervals (CI). Results: The meta-analysis was performed by RevMan software and significant association was observed in the dominant (AA versus AC+CC, P=0.05), recessive (CC versus AA+AC, P=0.02) and allelic (A versus C, P=0.04) models respectively. Conclusion: The ‘C’ allele is statistically associated with an elevated hypertension risk in Indian populations.