A systematic review and meta-analysis of effect of synthetic erythropoietin on hemoglobin in dialysis patients-Reference-Cited by-同舟云学术

A systematic review and meta-analysis of effect of synthetic erythropoietin on hemoglobin in dialysis patients

Published:2021-05-18 Issue:4 Volume:10 Page:e28-e28
ISSN:2345-2781
Container-title:Journal of Renal Injury Prevention
language:en
Short-container-title:J Renal Inj Prev

Author:

Nourmohammadi Hassan¹^ORCID,Abdan Zahra²^ORCID,Ramezanpour Melina³^ORCID,Abdollahipour Razieh⁴^ORCID,Sarokhani Diana⁵^ORCID,Fakhri Moloud⁶^ORCID,Hasanpour Dehkordi Ali⁷^ORCID

Affiliation:

1. Department of Internal Medicine Shahid Mostafa Khomeini Hospital, Ilam, Iran

2. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

3. Medical Student at Medical School, Mazandaran University of Medical Sciences, Sari, Iran

4. Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences; Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

5. Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

6. Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran

7. Social Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Introduction: Anemia is a common complication of chronic kidney disease (CKD) due to the insufficient production of erythropoietin by the kidneys. The administration of erythropoietin is one of the most common methods for the treatment of patients with anemia. Objectives: This study aimed to investigate the effect of the administration of synthetic erythropoietin on hemoglobin levels in dialysis patients using a systematic review and meta-analysis. Methods: In order to identify the related studies, the international databases of Web of Science, PubMed, Scopus, and Embase were searched from 2015 to 2020 using standard and valid keywords. The data were analyzed using STATA software (version 14), and a p-value of less than 0.05 was considered statistically significant. Results: In 12 reviewed articles with a sample size of 4,060 individuals, the standard effect size of the effect of synthetic erythropoietin on Hb in dialysis patients was reported as 2.08 (95% CI: 1.53-2.63), which was statistically significant; however, erythropoietin biosimilars did not show similar results. Conclusion: The administration of erythropoietin to hemodialysis patients increases Hb levels by more than 2 units.

Publisher

Maad Rayan Publishing Company

Subject

Urology,Nephrology

Link

http://journalrip.com/PDF/jrip-10-e28.pdf