The soluble major histocompatibility complex class I chain-related gene A (sMICA) as an early biomarker for diagnosing acute myocardial infarction

Abstract

Introduction: It is necessary to identify tests that have high diagnostic power in the early hours of acute myocardial infarction. Objectives: In this study, we investigated the major histocompatibility complex class I chain-related molecule A (MICA) in the serum of patients with myocardial infarction (MI). Patients and Methods: In this study, 65 patients with MI were studied. Creatine phosphokinase-MB (CPK-MB), troponin I, and MICA biomarkers were measured at different times after hospitalization (0, 3, 6, 9, 12 and, 24 hours). These biomarkers were evaluated at different times after chest pain (0 to 3, 3 to 6, and more than 6 hours). Results: Serum MICA biomarker increased significantly from admission to the hospital until 3 hours. Later on, it decreased until 24 hours. However, CPK-MB biomarkers as well as troponin I, change from admission up to 24 hours. Regarding diagnostic power, it was found that the diagnostic power of MICA is high in the early hours which indicates the high diagnostic power of the test. Conclusion: The diagnostic value of MICA is significant in the early hours after MI. Therefore, due to the high accuracy of MICA in diagnosing MI, it should be used as a diagnostic test along with other tests to confirm MI in the early hours.