Is There a Change in Platelet Indices Among Pregnant With Anti Phospholipid Syndrome?

Abstract

Introduction: Recurrent pregnancy loss (RPL) is a common obstetrical complication, where 50% have undetermined etiology. Antiphospholipid syndrome (APL) is an autoimmune disease documented as a cause of RPL. Thrombophilia, particularly platelet abnormalities, were accredited for RPL. Objectives: The purpose of this study is to determine the change in platelets parameters; specifically, platelet count, mean platelet volume (MPV), platelet distribution width PDW, in patients suffering from RPL caused by the anti-phospholipid syndrome. Patients and Methods: Fifty women with a confirmed diagnosis of APL syndrome having a history of RPL were assigned as a study group and fifty women who gave birth without RPL were set as healthy controls were taken from al Yarmouk teaching hospitals in Baghdad. The personal data were taken by direct interview with patients, and blood samples were taken and analyzed for complete blood counts and platelets indices. Results: Both platelets count and PDW scored significant correlation with the number of pregnancy loss; Pearson's correlation coefficient was (0.74,0.59) respectively for both variables. The ROC evaluated platelets count a cutoff value of 230 ,88%,84% respective sensitivity and specificities, AUC =0.89,and P-value<0.001 respectively. As for PDW it had a cutoff value of 13.6 fl/L,88%,80% respective sensitivity and specificities, AUC=0.87,and P-value<0.001. Conclusions: Platelet indicators may aid gynecologists' in low-resource settings in predicting high-risk pregnancies deemed to suffer from RPL .