Evaluation of mast cell count in oral and cutaneous lichen planus lesions

Author:

Koochak Dezfouli Mohammad12ORCID,Montazer Fatemeh3ORCID,Shiva Atena12ORCID,Moosazadeh Mahmood4ORCID,Biglari Abhari Maryam5ORCID,Alidoust Hadi6ORCID,Zamanzadeh Maryam12ORCID

Affiliation:

1. Department of Oral and Maxillofacial Pathology, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

2. Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran

3. Dermatopathologist, Department of Pathology, Iran University of Medical Sciences, Tehran, Iran

4. Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran

5. Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

6. Dentist, Tehran, Iran

Abstract

Introduction: Lichen planus (LP) is a relatively common chronic mucocutaneous disorder diagnosed based on clinical manifestations and histopathological findings. Mast cells (MCs) are multifunctional immune cells that are involved in the pathogenesis of LP by releasing certain chemical mediators. Objectives: The purpose of this comparative study was to estimate the number of intact (granulated), degranulated and total MCs in oral lichen planus (OLP) and cutaneous lichen planus (CLP) lesions. Patients and Methods: The present descriptive-analytical and cross-sectional study was conducted on 125 LP blocks, including 40 OLP samples and 85 CLP samples. The mean number of granulated, degranulated and total MCs were counted under light microscope (×100 and ×400). Data were analyzed by SPSS version 24 software using Mann-Whitney U and Pearson’s chi-square tests. Results: The mean total MC count was 14.92 ± 3.90 in OLP samples and 14.04 ± 5.60 in CLP samples respectively which was not statistically significant. The mean granulated MC count in CLP (10.53 ± 5.70) was higher than in OLP (4.34 ± 3.46) (P<0.001). The mean degranulated MC count in OLP (10.57 ± 2.99) was higher than in CLP (3.51 ± 2.72) (P<0.001). Conclusion: No statistically significant difference was observed in the total MC count between OLP and CLP; however the difference in the degranulated MC count was detected between OLP and CLP. Despite the homogeneity in the total MC count, the MCs appear to play different pathological roles in OLP and CLP.

Publisher

Maad Rayan Publishing Company

Subject

Immunology and Microbiology (miscellaneous),Hematology,Immunology,Endocrinology, Diabetes and Metabolism

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3