Synthesis and In Vitro Antibacterial Evaluation of Schiff Bases Derived FROM 2-Chloro-3-Quinolinecarboxaldehyde

Author:

Beyzaei Hamid1ORCID,Hosseini Moghadam Hadis1,Bagherzade Ghodsieh2,Aryan Reza1,Moghaddam-Manesh Mohammadreza3

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

2. Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran

3. General Bureau of Standard Sistan and Baluchestan Province, Iranian National Standards Organization

Abstract

Background: Design, identification, and synthesis of new antimicrobial agents along with preventive proceedings are essential to confront antibiotic-resistant pathogenic bacteria. Heterocyclic Schiff bases are biologically important compounds whose antimicrobial potentials have been proven to bacterial and fungal pathogens. Objectives: In this study, some quinoline Schiff bases were synthesized from condensation of 2-chloro3-quinolinecarboxaldehyde and aniline derivatives. Their inhibitory activities were evaluated against 6 gram-positive and 2 gram-negative bacterial pathogens. Methods: Disc diffusion, broth microdilution, and time-kill tests were applied according to the CLSI guidelines to determine IZD, MIC, and MBC values. Results: 2-Chloro-3-quinolinecarboxaldehyde Schiff bases could inhibit the growth of bacteria with IZDs of 7.5-19.8 mm, MICs of 256-2048 μg mL-1, and MBCs of 512 to ≥2048 μg mL-1. Conclusion: Moderate antibacterial effects were observed with heterocyclic Schiff bases. Complexation and structural changes can improve their antimicrobial properties.

Publisher

Maad Rayan Publishing Company

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