Histopathologic and Immunohistochemical Characterization of Human Gastric Oxyntic Mucosa with Parietal Cell Protrusions and Investigation into the Association Between Such Mucosal Changes of the Stomach and Use of Proton Pump Inhibitors

Author:

Naruki Saeko1,Fujino Takashi1,Ohnuma Shigeko1,Endo Akira1,Koizumi Hirotaka1,Kato Yo2,Takagi Masayuki1

Affiliation:

1. Department of Pathology, St. Marianna University School of Medicine

2. Department of Pathology, Nikko Medical Center, Dokkyo Medical University

Publisher

Marianna University Society of Medical Science

Reference36 articles.

1. 1) Karam SM, Straiton T, Hassan WM, Leblond CP. Defining epithelial cell progenitors in the human oxyntic mucosa. Stem Cells 2003; 21: 322–336.

2. 2) Vanderhoff BT, Tahboub RM. Proton pump inhibitors: An update. Am Fam Physician 2002; 66: 273–280.

3. 3) Hoogerwerf WA, Pasricha PJ. Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease. In: Brunton LL, Lazo SS, Parker KL (eds). Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 11th ed, McGraw-Hill, New York, 2006: 967–981.

4. 4) Matsuzaki J, Suzuki H, Minegishi Y, Sugai E, Tsugawa H, Yasui M, et al. Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse. Dig Dis Sci 2010; 55: 3339–3348.

5. 5) Stolte M, Bethke B, Seifert E, Armbrecht U, Lutke A, Goldbrunner P, et al. Observation of gastric glandular cysts in the corpus mucosa of the stomach under omeprazole treatment. Z Gastroenterol 1995; 33: 146–149.

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