Treatment of Hepatitis C with Glecaprevir/Pibrentasvir in a Patient with Concurrent Stricturing Crohn’s Disease on Adalimumab

Abstract

A 22-year-old male with long standing, active Crohn’s disease on Adalimumab had presented with increasing levels of his transaminases. A full workup was conducted and the patient was found to have hepatitis C (HCV) based on a positive HCV antibody, polymerase chain reaction (PCR) and genotyping. He was started on a regimen of Glecaprevir/Pibrentasvir with excellent response defined by complete normalization of his transaminitis and an undetectable PCR at the end of 8 weeks of treatment and achieved sustained viral response at 12 weeks of treatment. This is the first case reporting the use of a combination of Glecaprevir/Pibrentasvir and Adalimumab in a patient with HCV and Crohn’s disease. Key words: Hepatitis C, Glecaprevir/Pibrentasvir, Crohn’s Disease