Increased Expression of NLRP3 Inflammasome in Placentas of Gestational Hypertension

Abstract

Node like receptor pyrin 3 is a tripartite protein composed an amino terminal pyrin domin (PYD), nucleotide binding NACHT domine and a carboxy terminal leucinerich repeat (LRR) domine, and consider an intracellular sensor that detects a broad range signal and resulting in the formation and activation the NLRP3 inflammasome. This complex lead to release of the inflammatory cytokines IL-1β, IL-18 which is important for host defense against invading pathogen. Modern evidence indicates that the NLRP3 inflammasome involved in gestational hypertension. This study was conducted on fifty pregnant women and divided into two groups, 25 placentas from normotensive mother having no hypertension before as control group and 25 from gestational hypertension women as gestational hypertension group, obtained from Department of Obstetrics and Gynecology in Almosil El Aam Hospital and Alkhanssa Teaching Hospital, Mosul city, Iraq. The placental tissue samples were collected from central region and processed for immunohistochemical technique to expression of NLRP3 in placental tissue. The immunohistochemical study of placenta of gestational hypertension group showed the localization of NLRP3 protein and staining intensity in trophoblast, stroma and endothelium villi were high quantification compared with placenta from control group.