Development of D.M. Zubairov ideas by the Chita school of hemostasis

Abstract

Review is dedicated to the influence D.M. Zubairov ideas on the further research of hemostasis system in Chita scientific school. Even in 1957, D.M. Zubairov showed that the state of coagulation largely depends upon the reflex reactions from chemo- and baroreceptors of the carotid sinus and aortic arch. Building on this theory, we established that reflex reactions of hemostatic system can arise not only from known receptor zones, but also originate from the vessels of kidney, liver, lung and other organs. D.M. Zubairov et al. in 1963 dispelled the myth of the non-wetting vascular endothelium, ostensibly to retain the liquid state of the blood. Later we have shown that the increase in the potential difference between the intima and adventitia increased regardless of primary or secondary hypercoagulability. Our data indicate that when the crash syndrome lymph fibrinolysis is 23 times faster compared to the blood, which indicates a better adaptability against thrombosis. We have established the proof for the role of hemostatic system as a cellular regulator of the functional activity and survival. Pathological conditions associated with significant increase in the coagulation process, may not only lead to disseminated intravascular coagulation but also blood, extracellular fluid and cytoplasm of cells coagulation - a syndrome of intra- and extravasal coagulation. To date we can not tell the threshold determining when the hemostasis system is a cell regulator and when «executioner». Development of D.M. Zubairov ideas have led to new concepts of the «continuous liquid coagulation», «common transport system of the body», which helped to produce effective prophylactic and therapeutic methods for a significant umber of life threatening conditions.