Does dioxin exert toxic effects in humans at or near current background body levels?: an evidence-based conclusion

Author:

Guzelian P,Quattrochi L1,Karch N2,Aylward L3,Kaley R4

Affiliation:

1. University of Colorado Health Science Center, Box B-146, 4200 East 9th Avenue, BRB 723, Denver, CO 80262, USA

2. 1730 Rhode Island Avenue, N.W. Suite 1100, Washington, DC 20036, USA

3. 1800 Diagonal Rd., Suite 300, Alexandria, VA 22314, USA

4. 200 S. Hanley Rd., Suite 300, St. Louis, MO 63105, USA

Abstract

Evidence-based toxicology like evidence-based medicine, provides scientifically grounded evidence-based conclusions as distinguished from authority-based opinions. As an example, we address a proposition from the US Environmental Protection Agency's (EPA) Draft Dioxin [2,3, 7,8-tetrachlorodibenzo-P-dioxin (TCDD)] reassessment that: ‘dioxin... can produce effects... at or near current background body burdens or intake levels’. Guided by a systematic, objective, and unbiased analysis of the available molecular, physiological, and clinical/epidemiologic data, in accordance with accepted principles of scientific logic, we reach the evidence-based conclusion that the proposition is rejected. When gaps in scientific knowledge necessitate formulation of opinions to meet preventive or precautionary goals, the reversion to authority should be explicitly acknowledged.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

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