Recent advances in understanding transforming growth factor β regulation of orofacial development-Reference-Cited by-同舟云学术

Recent advances in understanding transforming growth factor β regulation of orofacial development

Published:2005-01 Issue:1 Volume:24 Page:1-12
ISSN:0960-3271
Container-title:Human & Experimental Toxicology
language:en
Short-container-title:Hum Exp Toxicol

Author:

Greene Robert M¹,Pisano M Michele²

Affiliation:

1. University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA; University of Louisville, Birth Defects Center, 501 S. Preston Street, Suite 301, Louisville, KY 40292, USA

2. University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA

Abstract

Members of the transforming growth factor (TGF) family have emerged as critical contributors to the choreography of cellular and tissue interactions underlying morphogenesis of the orofacial region. The TGFs β, and their downstream effector molecules, the Smads, play a pivotal role in normal as well as abnormal development of first branchial arch structures. Components of the TGFβ signal transduction machinery are discussed in relation to regulation of transcription, cell division and tissue differentiation in developing orofacial tissue, as evidence for a functional linkage between the TGFβ and retinoic acid signal transduction pathways during orofacial development.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1191/0960327105ht492oa

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