EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis

Abstract

Approximately one-third of membranous glomerulonephritis (MGN) cases in adults are associated with systemic diseases, including systemic lupus erythematosus(SLE) or malignancies. Malignancy-associated glomerulonephritis is rarely found in non-Hodgkin’s lymphoma (NHL). Epstein-Barr virus (EBV) has been postulated to contribute to the pathogenesis of both SLE and NHL. We described a 37-year-oldwoman with nephrotic syndrome who presented with clinical features of SLE and renal-biopsy revealed lupus MGN. The patient also suffered from concomitant progressive lymphadenopathyand NHL (diffuse large B-cell type) was demonstratedby neck lymph node biopsy. Serologic studies demonstratedEBV infection and specific EBV antigenswere present on lymph node and metastatic sites. We offer a discussion regarding the complex relationships between SLE, NHL, MGN and EBV.