Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness-Reference-Cited by-同舟云学术

Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness

Published:2001-06 Issue:5-10 Volume:17 Page:294-297
ISSN:0748-2337
Container-title:Toxicology and Industrial Health
language:en
Short-container-title:Toxicol Ind Health

Author:

Henderson Rogene F¹,Barr Edward B²,Blackwell Walter B²,Clark Connie R³,Conn Carole A²,Kalra Roma²,March Thomas H²,Sopori Mohan L²,Tesfaigzi Yohannes²,Ménache Margaret G²,Mash Deborah C⁴,Dokladny Karol⁵,Kozak Wieslaw⁶,Kozak Anna⁶,Wachulec Maceij⁶,Rudolph Karin²,Kluger Matthew J⁶,Singh Shashi P²,Razani-Boroujerdi Seddigheh²,Langley Raymond J²

Affiliation:

1. Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA,

2. Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA

3. US Army Medical Research Institute of Chemical Defense, Aberdeen, Maryland, USA

4. University of Miami, Miami, Florida, USA

5. University of New Mexico, Albuquerque, New Mexico 87108-5127, USA

6. Medical College of Georgia, Augusta, Georgia, USA

Abstract

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Publisher

SAGE Publications

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1191/0748233701th105oa

Reference3 articles.

1. Effects of Sarin on Temperature and Activity of Rats as a Model for Gulf War Syndrome Neuroregulatory Functions

2. Response of Rats to Low Levels of Sarin

3. Subclinical Doses of the Nerve Gas Sarin Impair T Cell Responses through the Autonomic Nervous System

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