Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion-Reference-Cited by-同舟云学术

Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion

Published:2004-11 Issue:4 Volume:9 Page:293-301
ISSN:1358-863X
Container-title:Vascular Medicine
language:en
Short-container-title:Vasc Med

Author:

Brass Eric P¹,Hiatt William R²,Green Simon³

Affiliation:

1. Center for Clinical Pharmacology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA

2. Department of Medicine, Divisions of Geriatrics and Cardiology, Section of Vascular Medicine, University of Colorado Health Sciences Center and the Colorado Prevention Center, Denver, CO, USA,

3. School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, Australia

Abstract

Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1191/1358863x04vm572ra

Reference83 articles.

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5. Adaptation of mitochondrial ATP production in human skeletal muscle to endurance training and detraining

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