Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation-Reference-Cited by-同舟云学术

Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Published:2004-06 Issue:3 Volume:10 Page:284-289
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Healey Kathleen M¹,Pavletic Steven Z²,Al-Omaishi Jinan¹,Leuschen M Patricia³,Pirruccello Samuel J⁴,Filipi Mary L¹,Enke Charles⁵,Ursick Mary Margaret⁶,Hahn Francis⁷,Bowen J D⁸,Nash Richard A⁹

Affiliation:

1. Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA

2. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA,

3. Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA, Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA

4. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

5. Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA

6. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA

7. Department of Radiology, University of Nebraska Medical Center, Omaha, NE, USA

8. Department of Neurology, University of Washington, Seattle, WA, USA

9. Fred Hutchinson Cancer Research Center of the University of Washington, Seattle, WA, USA

Abstract

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and C SF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantatio n strategies for this disease.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1191/1352458504ms1022oa

Reference23 articles.

1. Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis

2. Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation–based conditioning regimen to prevent disease progression in patients with high disability scores

3. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: Report of toxicity and immunological monitoring

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hematopoietic stem cell transplantation for multiple sclerosis;Handbook of Clinical Neurology;2024

2. Autologous Stem Cell Transplantation for Autoimmune Diseases;Comprehensive Hematology and Stem Cell Research;2024

3. Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications;Cells;2022-07-11

4. Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party;Frontiers in Immunology;2022-02-01

5. Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity;Metabolic Brain Disease;2021-04-28