High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up study-Reference-Cited by-同舟云学术

High clinical inflammatory activity prior to the development of secondary progression: a prospective 5-year follow-up study

Published:2002-02 Issue:1 Volume:8 Page:59-63
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Casanova B¹,Coret F²,Valero C³,Landete L⁴,Pascual A²,Vilchez J J³

Affiliation:

1. Neurology Services of the University Hospital La Fe, Valencia, Spain,

2. The Clinic University Hospital, Valencia, Spain

3. Neurology Services of the University Hospital La Fe, Valencia, Spain

4. The University Hospital, Dr. Peset, Valencia, Spain

Abstract

Objective: To study if there are different patterns of clinical activity - measured by the annual exacerbation rate (AER) - among relapsing-remitting multiple sclerosis (RRMS), “early” secondary multiple sclerosis (SPMS) and “late” SPMS. Methods: A prospective 5-year follow-up study in 80 MS patients has been carried out, calculating the AER and the mean expanded disability status scale (EDSS) change rate (MCR). Results: A significant difference on the AER, among RRMS, early SPMS and late SPMS, has been found. Conclusions: The SPMS has a high clinical inflammatory activity before and during its transformation from a RRMS.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1191/1352458502ms773oa

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