Multiple sclerosis characteristics in A frican A merican patients in the New York State Multiple Sclerosis C onsortium

Author:

Weinstock-Guttman B1,Jacobs L D2,Brownscheidle C M3,Baier M4,Rea D F3,Apatoff B R5,Blitz K M6,Coyle P K7,Frontera A T8,Goodman A D9,Gottesman M H10,Herbert J11,Holub R12,Lava N S13,Lenihan M14,Lusins J15,Mihai C16,Miller A E17,Perel A B18,Snyder D H19,Bakshi R3,Granger C V20,Greenberg S J3,Jubelt B16,Krupp L7,Munschauer F E3,Rubin D10,Schwid S9,Smiroldo J7,

Affiliation:

1. William C. Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA,

2. William C. Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA, Deceased

3. William C. Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA

4. Center for Research Methodology and Biometrics, AMC Cancer Research Center, Lakewood, CO 80214, USA

5. Department of Neurology and Neuroscience, Cornell Medical Center, New York, NY 10021, USA

6. Multiple Sclerosis Care Center, North Shore University Hospital at East Meadow, East Meadow, NY 11554, USA

7. Department of Neurology, State University of New York at Stony Brook University Hospital, Stony Brook, NY 11794, USA

8. Kingston Neurological Associates, Kingston, NY 12401, USA

9. Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA

10. Division of Neurology, Winthrop-University Hospital, Mineola, NY 11501, USA

11. The Hospital for Joint Diseases/Orthopedic Institute, MS Care Center, New York, NY 10003, USA

12. Neurological Associates of Albany, Albany, NY 12208, USA

13. Department of Neurology, Albany Medical College, Albany, NY 12208, USA

14. Glens Falls Neurology, Glens Falls, NY 12801, USA

15. Catskill Neuroscience and Radiology Associates, Oneonta, NY 13820, USA

16. Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

17. Division of Neurology, Maimonides Medical Center, Brooklyn, NY 11219, USA

18. Staten Island University Hospital, Staten Island, NY 10306, USA

19. New York Hospital Medical Center of Queens, Flushing, NY 11355, USA

20. Uniform Data System for Medical Rehabilitation, State University of New York at Buffalo

Abstract

The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in A frican A merican (A A) patients in the New York State Multiple Sclerosis C onsortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AA s comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in A A registrants versus nonA frican A mericans (NA A). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. A A patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. O ur findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

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