Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions-Reference-Cited by-同舟云学术

Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions

Published:2006-08 Issue:4 Volume:12 Page:369-374
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Merkler D¹,Schmelting B²,Czéh B²,Fuchs E³,Stadelmann C¹,Brück W⁴

Affiliation:

1. Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany

2. Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany

3. Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany, Institut für Multiple-Sklerose-Forschung, Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie-Stiftung, Göttingen, Germany, Department of Neurology, Georg-August University Göttingen, Göttingen, Germany

4. Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany, Institut für Multiple-Sklerose-Forschung, Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie-Stiftung, Göttingen, Germany,

Abstract

Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern II lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS.

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1191/1352458506ms1290oa

Reference23 articles.

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