Lupus in the family—analysis of a cohort followed from 1978 to 1999

Author:

Giles I1,Isenberg D2

Affiliation:

1. Centre for Rheumatology Bloomsbury Rheumatology Unit, Department of Medicine, University College London, London, UK; Centre for Rheumatology, Arthur Stanley House, 40-50 Tottenham Street, London W1P 9PG, UK

2. Centre for Rheumatology Bloomsbury Rheumatology Unit, Department of Medicine, University College London, London, UK

Abstract

Familial lupus is recognised but rarely described in mother-daughter case pairs. We describe the prevalence of lupus occurring in the first degree relatives of a cohort of 300 lupus patients under long-term follow-up at a specialised lupus clinic. Three instances of mothers and their daughters who both developed the disease are described in detail to try and ascertain whether there are any particular clinical/serological/genetic factors in common which might explain the phenomenon.

Publisher

SAGE Publications

Subject

Rheumatology

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