1. Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada N6A 5K8; Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada
2. Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada; Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada
3. Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada