Abstract
Spinal cord injury (SCI) is a severe and debilitating condition that often leads to significant and permanent neurological deficits, affecting motor, sensory, and autonomic functions. The high prevalence of SCI and the lack of effective treatments make it a critical area of medical research. Recent studies have shown promising prospects for fibroblast growth factors (FGF) in the treatment of SCI. FGF, particularly FGF-1 and FGF-2, are known to promote cell growth, differentiation, and survival, and have been demonstrated to enhance axonal regeneration and functional recovery in SCI models. This review highlights the roles of various FGF in neuroprotection, axonal regeneration, and remyelination. It also discusses the potential therapeutic applications of FGF in SCI treatment, emphasizing their ability to reduce neuroinflammation, oxidative stress, and promote motor function recovery. The comprehensive overview of existing research underscores the importance of FGF in SCI repair and suggests further exploration into their therapeutic potential.