Novel biomarkers of inflammation for endothelial dysfunction in chronic kidney disease patients

Abstract

Introduction and Aim: One of the main complications of chronic kidney diseases (CKD) resulting in morbidity and mortality is cardiac complications. High-sensitive C -reactive protein (hs- CRP), a novel biomarker of systemic inflammation is elevated in all the stages of kidney impairment. This leads to endothelial dysfunction resulting in cardiovascular complications.  The aim is to evaluate the levels of novel inflammatory biomarkers for endothelial dysfunction which could predict cardiovascular risk in CKD patients. Materials and Methods: This cross-sectional study was conducted among 50 CKD patients at a tertiary care hospital in Chennai. Study participants were from both sexes, aged between 20 and 65 years. Fasting blood samples were drawn for analysis of lipid profile, hs- CRP, calcium and phosphorus. Results: The participants were grouped into three based on the hs-CRP Levels, as Low (<0.80 mg/L), Medium (0.81–1.76 mg/L) and High (>1.76 mg/L). Serum creatinine was significantly increased (P=0.007) across the groups. hs-CRP showed positive correlation with creatinine, while it showed negative correlation with HDLc. Conclusion: Highly sensitive CRP is a marker of endothelial dysfunction. Elevated hsCRP levels in CKD patients indicate that they are prone for cardiovascular complications. Early detection of systemic low-grade inflammation may prevent future cardiovascular complications.