A study on changes in hormonal disruption in polycystic ovary syndrome with advancing age and body mass index

Abstract

Introduction and Aim: Polycystic ovary syndrome is a diverse condition that contributes to metabolic problems like insulin resistance and hyperandrogenism which women experience during their reproductive years, and it is closely related to the body mass index. The purpose of this study was to evaluate the clinical, biochemical, and hormonal profiles of PCOS patients and healthy women concerning age and BMI and to correlate insulin with other parameters.   Materials and Methods: The present case-control study was conducted from June 2019-April 2021. 180 PCOS women and 170 age-matched healthy women were enrolled from Mangalore, Karnataka. Anthropometric measurements, biochemical, hormonal profile, and the presence of IR were estimated in all patients and were further subdivided based on age and BMI.   Results: The mean age of patients with PCOS and controls was 25.9± 5.6 years vs 24.7 ± 6.8 years. BMI and WHR had statistical significance (p<0.01) between the groups. TG & HDL showed statistical significance (p<0.05) in both age groups who were underweight and had normal BMI. A significant difference (p<0.05) was also observed in plasma insulin and HOMA-IR in all groups except in women who were obese.   Conclusion: PCOS women were presented with hyperandrogenism and had metabolic risk factors like insulin resistance and low HDL-C levels at budding age and increased BMI. When comparing women with and without PCOS from the south Indian state of Karnataka, our findings revealed that changes in sex hormone levels had no significant impact on age or BMI.