Author:
V. Hegde Shreelaxmi,Adhikari Prabha,M. Kotian Shashidhar,Manjrekar Poornima,Shastry Rajeshwari,D’Souza Vivian
Abstract
Introduction and Aim: Large body of evidence suggests that oxidative stress has a crucial role to play in diabetes and its related complications. In the present research we have tried to determine potential risk factors for oxidative stress in type 2 diabetes by conducting a cross-sectional study.
Materials and Methods: We studied 238 patients with or without complications of diabetes, aged 40-75 years. Blood samples were analysed for fasting plasma glucose, glycated haemoglobin, malondialdehyde, total cholesterol, triglyceride, LDL-cholesterol and HDL-cholesterol. Each patient’s waist circumference, BMI, blood pressure was measured.
Results: Participants mean age was 57.5 ± 8.9 years. Logistic regression analysis identified glycated haemoglobin (95% CI: 1.02-1.92; p=0.04), hypertension (95% CI: 0.99-4.08; p=0.05) and LDL-cholesterol (95% CI: 1.12-5.87; p=0.03) as independent risk factors for oxidative stress. Other contributors were age and presence of complications like nephropathy, retinopathy, peripheral neuropathy and macrovascular disease in diabetes.
Conclusion: Our data demonstrate that ‘ABCs of diabetes’ namely HbA1c, blood pressure and LDL-cholesterol are independent risk factors for oxidative stress. Oxidative stress aggravates with age and presence of complications. It appears important to achieve a good ABC goal to bring down oxidative stress in diabetes.
Publisher
Indian Association of Biomedical Scientists
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference21 articles.
1. Tangvarasittichai, S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J. Diabetes. 2015; 6(3): 456-480.
2. Brownlee, M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005; 54(6): 1615-1625.
3. Geraldes, P., King, G.L. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ. Res. 2010; 106(8): 1319-1331.
4. Kawamura, M., Heinecke, J.W., Chait, J. Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. J Clin Invest. 1994; 94(2): 771-778.
5. Behradmanesh, S., Derees, F., Rafi eian-kopaei, M. Effect of Salvia officinalis on diabetic patients. J Renal Inj Prev. 2013; 2(2): 55-59.