The altered levels of adiponectin - leptin as predictive biomarkers to estimate the severity of prostate cancer

Abstract

Introduction and Aim: Prostate is one of the commonest sites of malignancy affecting elderly male population & is increasingly becoming a significant public health issue especially in countries having aging population. We hypothesized that altered levels of adiponectin-leptins may be an underlying connection between incidence of prostate cancer (PCa) and aged matched males.   Materials and Methods: This study was designed to comparatively corelate circulating serum levels of adiponectin & leptin in 160 elderly patients with PCa to their serum levels in 160 healthy controls. The age and body mass index in all groups were dissimilar in case and control. Based on the Gleason score of 7, =7 >7, patients were further subdivided into low, intermediate, high grades of PCa, respectively.    Results: No significant statistical variance was identified in terms of age, Body mass index (BMI), Radom blood glucose, HDL, LDL, triglycerides, total cholesterol, creatinine, and BUN levels within the compared groups. In PCa patients’ group, concentration levels of serum adiponectin were significantly lower, and levels of serum leptin was significantly greater compared to healthy controls (P<0.001). Statistical analysis revealed a significant positive inverse association between PSA and adiponectin levels (r=0.285, P<0.001) and significant association between serum levels of PSA and leptin (r=0.285, P<0.001). Significant statistical correlation was also evident between BMI, PSA, TG, and leptin were whole group. However, there was no significant association observed between adiponectin or leptin level and grade of the disease.   Conclusion: Evaluation of data in our study suggests that patients of PCa exhibit low concentration of serum adiponectin levels and high concentration of leptin levels. Further, this association was independent of histological grading of disease of disease/disease progression as well as other biochemical parameters.