Preventive effect of sildenafil on right ventricular function in rats with monocrotaline-induced pulmonary arterial hypertension

Author:

Yoshiyuki Rieko1,Tanaka Ryo1,Fukushima Ryuji1,Machida Noboru2

Affiliation:

1. Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan

2. Department of Veterinary Clinical Oncology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference35 articles.

1. 1. Blanchard D.G., Malouf P.J., Gurudevan S.V., Auger W.R., Madani M.M., Thistlethwaite P., Waltman T.J., Daniels L.B., Raisinghani A.B., and DeMaria A.N. 2009. Utility of right ventricular Tei index in the noninvasive evaluation of chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy. JACC Cardiovasc. Imaging 2: 143–149.

2. 2. Borgdorff M.A., Bartelds B., Dickinson M.G., van Wiechen M.P., Steendijk P., de Vroomen M., and Berger R.M. 2014. Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload. Am. J. Physiol. Heart Circ. Physiol. 307: H361–H369.

3. 3. Buyukakilli B., Gurgul S., Citirik D., Hallioglu O., Ozeren M., and Tasdelen B. 2014. Determination of the effects of pulmonary arterial hypertension and therapy on the cardiovascular system of rats by impedance cardiography. Croat. Med. J. 55: 498–506.

4. 4. Carlino C., Tobias J.D., Schneider R.I., Heller R.L., Alpert M.A., Grueber R.E., Dellsperger K.C., and Demarco V.G. 2010. Pulmonary hemodynamic response to acute combination and monotherapy with sildenafil and brain natriuretic peptide in rats with monocrotaline-induced pulmonary hypertension. Am. J. Med. Sci. 339: 55–59.

5. 5. Condliffe R., Kiely D.G., Peacock A.J., Corris P.A., Gibbs J.S., Vrapi F., Das C., Elliot C.A., Johnson M., DeSoyza J., Torpy C., Goldsmith K., Hodgkins D., Hughes R.J., Pepke-Zaba J., and Coghlan J.G. 2009. Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era. Am. J. Respir. Crit. Care Med. 179: 151–157.

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