Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation

Author:

Saengklub Nakkawee1,Limprasutr Vudhiporn2,Sawangkoon Suwanakiet2,Hamlin Robert L.3,Kijtawornrat Anusak24

Affiliation:

1. Animal Physiology Program, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant Road, Pathumwan, Bangkok 10330, Thailand

2. Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant Road, Pathumwan, Bangkok 10330, Thailand

3. QTest Labs, Ltd., 6456 Fiesta Drive, Columbus, Ohio 43235, USA

4. Research clusters: research study and testing of drug’s effect related to cardiovascular system in laboratory animal, Chulalongkorn University, 39 Henri Dunant Road, Pathumwan, Bangkok 10330, Thailand

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference37 articles.

1. 1. Bicer S., Fuller G.A., Wilkie D.A., Yamaguchi M., and Hamlin R.L. 2002. Amiodarone-induced keratopathy in healthy dogs. Vet. Ophthalmol. 5: 35–38.

2. 2. Bicer S., Nakayama T., and Hamlin R.L. 2002. Effects of chronic oral amiodarone on left ventricular function, ECGs, serum chemistries, and exercise tolerance in healthy dogs. J. Vet. Intern. Med. 16: 247–254.

3. 3. Bogdan R., Goegelein H., and Ruetten H. 2009. Viable heart slices: action potential recordings from atrial and ventricular tissues. Acta Physiol. (Oxf.) 195:(suppl. 669): 64.

4. 4. Bogdan R., Goegelein H., and Ruetten H. 2011. Effect of dronedarone on Na+, Ca2+ and HCN channels. Naunyn Schmiedebergs Arch. Pharmacol. 383: 347–356.

5. 5. Burashnikov A., Di Diego J.M., Zygmunt A.C., Belardinelli L., and Antzelevitch C. 2007. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation 116: 1449–1457.

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