Reproducible insulin secretion from isolated rat pancreas preparations using an organ bath

Author:

Morita Asuka1,Ouchi Motoshi1,Terada Misao2,Kon Hiroe2,Kishimoto Satoko3,Satoh Keitaro4,Otani Naoyuki5,Hayashi Keitaro1,Fujita Tomoe1,Inoue Ken-ichi3,Anzai Naohiko6

Affiliation:

1. Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan

2. Laboratory Animal Research Center, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan

3. Research Support Center, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan

4. Department of Pharmacology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan

5. Department of Clinical Pharmacology and Therapeutics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan

6. Department of Pharmacology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference34 articles.

1. 1. Alberti K.G., Christensen N.J., Christensen S.E., Hansen A.P., Iversen J., Lundbaek K., Seyer-Hansen K., and Orskov H. 1973. Inhibition of insulin secretion by somatostatin. Lancet 302: 1299–1301.

2. 2. Asfari M., Janjic D., Meda P., Li G., Halban P.A., and Wollheim C.B. 1992. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130: 167–178.

3. 3. Babkin B.P. and Starling E.H. 1926. A method for the study of the perfused pancreas. J. Physiol. 61: 245–247.

4. 4. Boullin D.J., Costa E., and Brodie B.B. 1967. Evidence that blockade of adrenergic receptors causes overflow of norepinephrine in cats colon after nerve stimulation. J. Pharmacol. Exp. Ther. 157: 125–134.

5. 5. Campbell J.E. and Drucker D.J. 2013. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 17: 819–837.

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