Phenotypic and Expression Analysis of a Novel Spontaneous Myosin VI Null Mutant Mouse

Author:

MOCHIZUKI Eiji1,OKUMURA Kazuhiro1,ISHIKAWA Masashi1,YOSHIMOTO Sachi1,YAMAGUCHI Junya1,SEKI Yuta1,WADA Kenta1,YOKOHAMA Michinari1,USHIKI Tatsuo2,TOKANO Hisashi3,ISHII Rie4,SHITARA Hiroshi4,TAYA Choji4,KITAMURA Ken3,YONEKAWA Hiromichi4,KIKKAWA Yoshiaki14

Affiliation:

1. Department of Bioindustry, Tokyo University of Agriculture

2. Department of Anatomy, Graduate School of Medical and Dental Sciences, Niigata University

3. Department of Otolaryngology, Tokyo Medical and Dental University

4. Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference33 articles.

1. 1. Ahmed, Z.M., Morell, R.J., Riazuddin, S., Gropman, A., Shaukat, S., Ahmad, M.M., Mohiddin, S.A., Fananapazir, L., Caruso, R.C., Husnain, T., Khan, S.N., Riazuddin, S., Griffith, A.J., Friedman, T.B., and Wilcox, E.R. 2003. Mutations of MYO6 are associated with recessive deafness, DFNB37. Am. J. Hum. Genet. 72: 1315-1322.

2. The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene

3. 3. Anagnostopoulos, A.V. 2002. A compendium of mouse knockouts with inner ear defects. Trends Genet. 18: S21-38.

4. 4. Aula, P. and Gahl, W.A. 2001. Disorders of free sialic acid storage. pp. 5109-5120. In: The Metabolic and Molecular Bases of Inherited Disease, 8th ed. (Scriver, C.R., Beauded, A.L., Sly, W.E., and Valle, D. eds.), McGraw-Hill, New York.

5. The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells

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