Advantages of a Mouse Model for Human Hearing Impairment

Author:

Kikkawa Yoshiaki1,Seki Yuta1,Okumura Kazuhiro2,Ohshiba Yasuhiro13,Miyasaka Yuki13,Suzuki Sari14,Ozaki Mao14,Matsuoka Kunie1,Noguchi Yoshihiro5,Yonekawa Hiromichi6

Affiliation:

1. Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science

2. Laboratory of Experimental Animals, Chiba Cancer Center Research Institute

3. Graduate School of Medical and Dental Sciences, Niigata University

4. Department of Bioproduction, Tokyo University of Agriculture

5. Department of Otolaryngology, Tokyo Medical and Dental University

6. Basic Research Center, Tokyo Metropolitan Institute of Medical Science

Publisher

Japanese Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

Reference117 articles.

1. 1. Adato, A., Lefèvre, G., Delprat, B., Michel, V., Michalski, N., Chardenoux, S., Weil, D., El-Amraoui, A., and Petit, C. 2005. Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells. Hum. Mol. Genet. 14: 3921–3932.

2. 2. Adato, A., Michel, V., Kikkawa, Y., Reiners, J., Alagramam, K.N., Weil, D., Yonekawa, H., Wolfrum, U., El-Amraoui, A., and Petit, C. 2005. Interactions in the network of Usher syndrome type 1 proteins. Hum. Mol. Genet. 14: 347–356.

3. Mutations of MYO6 Are Associated with Recessive Deafness, DFNB37

4. Mutations of the Protocadherin Gene PCDH15 Cause Usher Syndrome Type 1F

5. The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene

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