Affiliation:
1. Moscow State University of Medicine and Dentistry; Еmergency Medical Care Station of A. S. Puchkov
Abstract
In 94 patients, suffering from complicated or uncomplicated hypertensic crisis, the efficiency and safety of esmolol administration in pre-hospital stage of emergency medical care was examined. Unique pharmacokinetics of esmolol allow us to achieve significant arterial tension decrease during the first minutes of the intravenous injection, meanwhile antihypertensive effect increases till 20 minutes and elimination half-life is 9 minutes. Esmolol dosage was selected depending on initial hemodynamic indicators and hypertensic crisis complications. In order to evaluate efficiency and safety in this research the following indicators were measured: sistolic blood pressure, diastolic blood pressure, heart rate, electrocardiogram and SpO2 , respiratory function monitoring.
Publisher
FSBEI HE I.P. Pavlov SPbSMU MOH Russia
Reference17 articles.
1. Reschetnikov A. V. Medicine sociology: guideline. St. Petersburg: Publishing house GEOTARMedia, 2010. 864 р. (In Russ.)
2. Nolan C. R. Hypertensive Crises // Schrier R. W., ed. Atlas of desease of the kidney. Vol. 3. Philadelphia: Current medicine, 1999.
3. Tereshchenko S. N., Plavunov N. F. Нypertensive crises. Moscow: Publishing house MEDpress inform Publishing house, 2011. 208 p. (In Russ.)
4. Guidelines for the diagnosis and treatment of non STsegment elevation acute coronary syndromes. The Task Force for the Diagnosis and Treatment of Non STSegment Elevation Acute Coronary Syndromes of the European Society of Cardioogy // Eur. Heart J. 2007. Vol. 28. P. 1598–1660.
5. Frishman W., Jacob H., Eisenberg E. et al. Clinical pharmacology of the new betaadrenergic blocking drugs. Part 8: selfpoisoning with betaadrenoceptor blocking agents: recognition and management // Am. Heart J. 1979. Vol. 98. P. 798–811.