EXPANDING THE FRONTIERS OF SUCCINATE-CONTAINING DIALYSATE’S EFFECTS-Reference-Cited by-同舟云学术

EXPANDING THE FRONTIERS OF SUCCINATE-CONTAINING DIALYSATE’S EFFECTS

Published:2017-03-03 Issue:1 Volume:21 Page:19-24
ISSN:2541-9439
Container-title:Nephrology (Saint-Petersburg)
language:
Short-container-title:Nefrologiâ (St.-Peterbg.)

Author:

Golubev R. V.¹,Smirnov A. V.¹

Affiliation:

1. Pavlov First Saint-Petersburg State Medical University

Abstract

Succinate is hypoxic stress signal metabolite. Entering the patient’s body from the dialysate during hemodialysis, succinate inhibits prolylhydroxylases, leading to stabilization of hypoxia-inducible factor (HIF) and to the deployment of many HIF-mediated effects. Application of succinate-containing dialysis solutions can be considered as pseudohypoxic preconditioning, which provides the beneficial effect on several clinical and biochemical parameters of patients.

Publisher

Non-profit organization Nephrology

Subject

Nephrology

Reference44 articles.

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