The role of connexin structures (gap-junction and hemichannels) in the pathogenesis of ischemic brain damage: status update on the problem-Reference-Cited by-同舟云学术

The role of connexin structures (gap-junction and hemichannels) in the pathogenesis of ischemic brain damage: status update on the problem

Published:2016-09-30 Issue:3 Volume:15 Page:4-14
ISSN:1682-6655
Container-title:Regional blood circulation and microcirculation
language:
Short-container-title:Regional blood circulation and microcirculation

Author:

Melnikova E. V.¹,Shmonin A. A.²,Paramonov N. M.³,Mishchenko K. A.⁴

Affiliation:

1. Pavlov First Saint-Petersburg State Medical University

2. Pavlov First Saint-Petersburg State Medical University; Federal Almazov North-West Medical Research Centre

3. Pavlov Institute of Physiology Russian Academy of Sciences

4. Outpatient department «Consult and Diagnostic Center and Outpatient department»

Abstract

This review is devoted to a discussion of the dual role of connexin intercellular structures and gap junction (GJ) in normal and cerebral ischemia. The review describes the structure and form of connexin structures such as gap junctions and hemichannels. It is shown that the properties of connexin structures depend on the connexins. We describe a substance that can be transported through connexin structure. The data on the possible increase in the number of GJ after ischemia/cerebral hypoxia. A hypothesis about the development of post-ischemic neuronal syncytium formation by GJ. We discuss ways of blocking of GJ to reduce post-ischemic brain damage.

Publisher

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Subject

General Medicine

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