Analysis of the causes of age-related decline in the velocity of cerebral blood flow

Abstract

Goal. Determining the causes of age-related decrease of blood flow velocity (BFV) in the middle cerebral artery (MCA) in healthy subjects and in patients during surgical lengthening of stunted limbs. Methods. BFV in MCA was determined by transcranial Doppler. The analysis of the indicator in functional muscle sample of 30 healthy people 18-60 years old and 30 patients 3-62 years of lagging in the growth of one of the lower limbs in the course of its operational extension. As an indicator of cerebral autoregulation used swing changes BFV indicators during the second holding muscle functional test. Results. The age-related reduction in flow rate in the middle cerebral artery was more pronounced in patients with disorders of the musculoskeletal system. At the same time, the average value of the magnitude of blood flow velocity index changes during the functional test in healthy individuals older than 10 years, as well as in patients before treatment and during the fixation is stable (17-25 %). Conclusion. Age-related decline in the BFV at MCA is a prerequisite for the preservation of cerebral autoregulation. Disorders of cerebral autoregulation in patients undergoing distraction of limbs greatly reduces their tolerance to physical exercise.