Coronary circulation and renewal of heart coronary disease clinic after intracoronary stenting

Abstract

Purpose. To evaluate the role of changes in coronary blood flow in ischemic heart disease clinic reopening after PCI. Materials and methods. The study included 90 patients with coronary heart disease by 40 to 75 years, who underwent emergency PCI (15 patients) and planned (75 patients) procedure. The risk of complications is calculated on a scale Syntax Score. We investigated the venous blood obtained before and after 6 and 12 months following PCI. In the same period, performed stress echocardiography. In case of resumption of CAD patients clinic conducted stress echocardiography and repeated PCI. The intensity of thrombin formation was assessed using a thrombin generation test (TGT) in platelet-poor plasma and the modified reaction mixture by adding human recombinant thrombomodulin (rh-TM) to assess the degree of activation of the protein C system. Results. A total of 4 years of observation, a total of 30 cases of coronary heart disease is ascertained clinic renewal. Despite the different risk of complications on a scale Syntax Score, the incidence of complications between the groups did not differ. Among the factors that determine the risk of complications during the first year of observation, the most important is the degree of stenosis of the left circumflex artery and a violation of regional contractility in the basin of the artery. In the development of complications of the next 3 years of follow up indicators of stress echocardiography, the intensity of the formation of thrombin and lack of exercise. Conclusions. It was found that CAD clinics renewal is not only a violation of the coronary blood flow. CAD risk clinical relapse rate also depends on the formation of thrombin and protein C system activity.