Author:
Zhang Lijuan, ,Ma Jian,Ma Xiaoyan,Feng Xin,Bai Xuesong,Huang Yongtao,Jayawardena Ruvishika S.,Mapook Ausana,Kang Jichuan,Lu Yongzhong, , , , , , , , , , , , , ,
Abstract
In a diversity study of helicosporous hyphomycetes, a new record viz. Neohelicosporium guangxiense was collected, isolated and identified based on multi-gene phylogenetic analyses and morphological evidence. In this study, secondary metabolites of N. guangxiense were also investigated, from which four compounds were isolated and identified, including three α-tetralon derivatives (1-3) and one isocoumarin derivative (4). This is the first time that these compounds were isolated from the fungal genus Neohelicosporium, and compound 1 was firstly isolated from natural resources. Their structures were assigned based on the extensive 1D/2D NMR spectroscopic analyses, ESI-MS, and HR-ESI-MS measurements, especially the 2D NMR spectra of compound 1 were described in detail, and the absolute configuration of compound 1 was also elucidated for the first time. Furthermore, the bioactivities of all compounds were inactive in our bioassays.
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Mathematics,General Chemistry