Otizm Spektrum Bozukluğu Olan Hastalarda Öğrenme ve Hafıza Bozukluklarının NEURL1 ve RGS14 Genleri ile İlişkisi

Abstract

Aim: We aimed to evaluate the relationship between learning-memory difficulties and NEURL1 and RGS14 genes in patients with autism spectrum disorders (ASD). Method: Forty children with ASD (20 ASD, 20 high functioning autism (HFA)) and 20 healthy controls were enrolled in this study. NEURL1 and RGS14 gene expressions in the blood samples of volunteers were assessed by quantitative Real-Time PCR (qRT-PCR). The clinical and demographical findings in patients were determined and examined relation with the gene expressions. Results: According to our findings, NEURL1 gene expression was decreased in both patient groups compared to the control (p0.05). A statistically significant correlation was found between learning and memory difficulties and RGS14 gene expression in HFA patients (p = 0.045). There was a positive correlation between between NEURL1 and RGS14 gene expressions of ASD patients (p=0.032, r=0,59). Conclusion: According to this study, NEURL1 gene may be proposed as a candidate gene for ASD. Nonetheless, we recommend that both genes be studied with more patients and preferably with brain tissues. These genes were evaluated for the first time in a clinical study on autism, and we believe that they will contribute to the literature in this respect.