İntravitreal Aflibercept Uygulanan Hastalarda Topikal Antiglokomatöz Damlanın Göziçi Basıncı Değişimine Etkisi

Abstract

Aim:The aim is to investigate the effect of using topical dorzolamide-timolol (DT) drops before intravitreal aflibercept (IVA) administration on intraocularpressure (IOP) changes. Materials and Methods: Forty-five eyes of 45 patients with diabetic retinopathy and macular edema who received DT drops 1 hour before IVA were considered as group 1, and 45 eyes of 45 patients without DT drops were considered as group 2. Patients who had previously undergone intravitreal injection, intraocular surgery, and who used any eye drops were excluded from the study. IOP values were measured with Tonopen contact handheld tonometer before blepharostatinsertion (BBIOP), after blepharostat insertion (ABIOP) and at 1 minute after injection (AIIOP). Results: There were 23 males and 22 females in group 1 and 22 males and 23 females in group 2 (p=0.96). The mean age was 55.23 ±7.53 years in group 1 and 55.70 ±9.78 years in group 2.(p=0. 97) In group 1, BBIOP was 18.12 ±4.18 mmHg, ABIOP 20.98 ±4.42 mmHg, AIIOP 43.20 ±15.80 mmHg, while in group 2, BBIOP 18.65 ±3.52 mmHg, ABIOP 22.80 ±3.90 mmHg, AIIOP 39.08 ±13.18 mmHg. The difference between AIIOP and BBIOP was 25.04 ±16.30 mmHg in group 1 and 20.36 ±13.82 mmHg in group 2, the difference was not statistically significant.(p=0.21) The difference between AIIOP and ABIOP was 22.32 ±16.48 mmHg in group 1 and 16.18 ±13.05 mmHg in group 2, the difference was statistically significant.(p=0.03). Conclusion: In the group using topical DT drops before IVA administration, BBIOP and ABIOP values were lower, while AIIOP values were higher.